BAI1
Brain Specific Angiogenesis Inhibitor 1 (BAI1)
Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas
Sequence length:
1584
Sequence:
MRGQAAAPGP VWILAPLLLL LLLLGRRARA AAGADAGPGP EPCATLVQGK
FFGYFSAAAV FPANASRCSW TLRNPDPRRY TLYMKVAKAP VPCSGPGRVR
TYQFDSFLES TRTYLGVESF DEVLRLCDPS APLAFLQASK QFLQMRRQQP
PQHDGLRPRA GPPGPTDDFS VEYLVVGNRN PSRAACQMLC RWLDACLAGS
RSSHPCGIMQ TPCACLGGEA GGPAAGPLAP RGDVCLRDAV AGGPENCLTS
LTQDRGGHGA TGGWKLWSLW GECTRDCGGG LQTRTRTCLP APGVEGGGCE
GVLEEGRQCN REACGPAGRT SSRSQSLRST DARRREELGD ELQQFGFPAP
QTGDPAAEEW SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC
NNSAVCPVHG AWDEWSPWSL CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE
KQTKFCNIAL CPGRAVDGNW NEWSSWSACS ASCSQGRQQR TRECNGPSYG
GAECQGHWVE TRDCFLQQCP VDGKWQAWAS WGSCSVTCGA GSQRRERVCS
GPFFGGAACQ GPQDEYRQCG TQRCPEPHEI CDEDNFGAVI WKETPAGEVA
AVRCPRNATG LILRRCELDE EGIAYWEPPT YIRCVSIDYR NIQMMTREHL
AKAQRGLPGE GVSEVIQTLV EISQDGTSYS GDLLSTIDVL RNMTEIFRRA
YYSPTPGDVQ NFVQILSNLL AEENRDKWEE AQLAGPNAKE LFRLVEDFVD
VIGFRMKDLR DAYQVTDNLV LSIHKLPASG ATDISFPMKG WRATGDWAKV
PEDRVTVSKS VFSTGLTEAD EASVFVVGTV LYRNLGSFLA LQRNTTVLNS
KVISVTVKPP PRSLRTPLEI EFAHMYNGTT NQTCILWDET DVPSSSAPPQ
LGPWSWRGCR TVPLDALRTR CLCDRLSTFA ILAQLSADAN MEKATLPSVT
LIVGCGVSSL TLLMLVIIYV SVWRYIRSER SVILINFCLS IISSNALILI
GQTQTRNKVM CTLVAAFLHF FFLSSFCWVL TEAWQSYMAV TGHLRNRLIR
KRFLCLGWGL PALVVAISVG FTKAKGYSTM NYCWLSLEGG LLYAFVGPAA
AVVLVNMVIG ILVFNKLVSK DGITDKKLKE RAGASLWSSC VVLPLLALTW
MSAVLAVTDR RSALFQILFA VFDSLEGFVI VMVHCILRRE VQDAVKCRVV
DRQEEGNGDS GGSFQNGHAQ LMTDFEKDVD LACRSVLNKD IAACRTATIT
GTLKRPSLPE EEKLKLAHAK GPPTNFNSLP ANVSKLHLHG SPRYPGGPLP
DFPNHSLTLK RDKAPKSSFV GDGDIFKKLD SELSRAQEKA LDTSYVILPT
ATATLRPKPK EEPKYSIHID QMPQTRLIHL STAPEASLPA RSPPSRQPPS
GGPPEAPPAQ PPPPPPPPPP PPQQPLPPPP NLEPAPPSLG DPGEPAAHPG
PSTGPSTKNE NVATLSVSSL ERRKSRYAEL DFEKIMHTRK RHQDMFQDLN
RKLQHAAEKD KEVLGPDSKP EKQQTPNKRP WESLRKAHGT PTWVKKELEP
LQPSPLELRS VEWERSGATI PLVGQDIIDL QTEV
Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas
Sequence length:
1584
Sequence:
MRGQAAAPGP VWILAPLLLL LLLLGRRARA AAGADAGPGP EPCATLVQGK
FFGYFSAAAV FPANASRCSW TLRNPDPRRY TLYMKVAKAP VPCSGPGRVR
TYQFDSFLES TRTYLGVESF DEVLRLCDPS APLAFLQASK QFLQMRRQQP
PQHDGLRPRA GPPGPTDDFS VEYLVVGNRN PSRAACQMLC RWLDACLAGS
RSSHPCGIMQ TPCACLGGEA GGPAAGPLAP RGDVCLRDAV AGGPENCLTS
LTQDRGGHGA TGGWKLWSLW GECTRDCGGG LQTRTRTCLP APGVEGGGCE
GVLEEGRQCN REACGPAGRT SSRSQSLRST DARRREELGD ELQQFGFPAP
QTGDPAAEEW SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC
NNSAVCPVHG AWDEWSPWSL CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE
KQTKFCNIAL CPGRAVDGNW NEWSSWSACS ASCSQGRQQR TRECNGPSYG
GAECQGHWVE TRDCFLQQCP VDGKWQAWAS WGSCSVTCGA GSQRRERVCS
GPFFGGAACQ GPQDEYRQCG TQRCPEPHEI CDEDNFGAVI WKETPAGEVA
AVRCPRNATG LILRRCELDE EGIAYWEPPT YIRCVSIDYR NIQMMTREHL
AKAQRGLPGE GVSEVIQTLV EISQDGTSYS GDLLSTIDVL RNMTEIFRRA
YYSPTPGDVQ NFVQILSNLL AEENRDKWEE AQLAGPNAKE LFRLVEDFVD
VIGFRMKDLR DAYQVTDNLV LSIHKLPASG ATDISFPMKG WRATGDWAKV
PEDRVTVSKS VFSTGLTEAD EASVFVVGTV LYRNLGSFLA LQRNTTVLNS
KVISVTVKPP PRSLRTPLEI EFAHMYNGTT NQTCILWDET DVPSSSAPPQ
LGPWSWRGCR TVPLDALRTR CLCDRLSTFA ILAQLSADAN MEKATLPSVT
LIVGCGVSSL TLLMLVIIYV SVWRYIRSER SVILINFCLS IISSNALILI
GQTQTRNKVM CTLVAAFLHF FFLSSFCWVL TEAWQSYMAV TGHLRNRLIR
KRFLCLGWGL PALVVAISVG FTKAKGYSTM NYCWLSLEGG LLYAFVGPAA
AVVLVNMVIG ILVFNKLVSK DGITDKKLKE RAGASLWSSC VVLPLLALTW
MSAVLAVTDR RSALFQILFA VFDSLEGFVI VMVHCILRRE VQDAVKCRVV
DRQEEGNGDS GGSFQNGHAQ LMTDFEKDVD LACRSVLNKD IAACRTATIT
GTLKRPSLPE EEKLKLAHAK GPPTNFNSLP ANVSKLHLHG SPRYPGGPLP
DFPNHSLTLK RDKAPKSSFV GDGDIFKKLD SELSRAQEKA LDTSYVILPT
ATATLRPKPK EEPKYSIHID QMPQTRLIHL STAPEASLPA RSPPSRQPPS
GGPPEAPPAQ PPPPPPPPPP PPQQPLPPPP NLEPAPPSLG DPGEPAAHPG
PSTGPSTKNE NVATLSVSSL ERRKSRYAEL DFEKIMHTRK RHQDMFQDLN
RKLQHAAEKD KEVLGPDSKP EKQQTPNKRP WESLRKAHGT PTWVKKELEP
LQPSPLELRS VEWERSGATI PLVGQDIIDL QTEV
